Mechanism is all you need

Spin Chemistry & Smart Chemistry

Publications

Representative papers
  1. Wang, J.†; Wang, S.†; Wei, Z. †; Wang, P.; Cao, Y.; Huang, Y; He, L.*; Lei, A.*; Synchronous recognition of amines in oxidative carbonylation toward unsymmetric ureas. Science, 2024, 386, 776.
  2. Wang, S.†; Luo, X. †; Wang, Y. †; Liu, Z.; Wang, X.; Wang, P.; Qi, X.*; Yi, H.*; Lei, A.*; Radical-triggered translocation of C–C double bond and functional group. Nature Chem., 2024, 16, 1621.
  3. Wang, S.†; Ren, D.†; Gao, Y.; Wang. P.; Wang, Y.; Qi, X.; Lei, A.*, Practical allylic fluoroalkylation of terpenes. Nature Synth., 2023, 2, 1202.
  4. Wang, S.†; Gao, Y.†; Ren, D.; Sun H.; Niu, L.; Yang, D.; Zhang, D.; Liang, X.; Shi, R.; Qi, X.*; Lei, A.*, Site-selective amination towards aliphatic allylamines. Nature Catal., 2022, 5, 642.
  5. Wang, S.; Lei, A.*, One electron is better than two. Nature Catal., 2023, 6, 220. (News & Views)
  6. Wang, S. †; Wang, P. †; Li, S. †; Chen, Y.-H.*; Sun, Z.*; Lei, A.*, Electrochemical flow aziridination of unactivated alkenes, Natl. Sci. Rev., 2023, 10, nwad187.
  7. Yu, W.†; Wang, S.†; He, M.; Jiang, Z.; Yu, Y.; Lan, J.; Luo, J.; Wang, P.; Qi, X.; Wang, T.*; Lei, A.*; Electroreduction enables regioselective 1,2-diarylation of alkenes with two electrophiles. Angew. Chem. Int. Ed., 2023, e202219166.
  8. Liu, S.†; Wang, S.†; Wang, P.; Huang, Z.*; Wang, T.*; Lei, A.*, 1,2-Amino oxygenation of alkenes with hydrogen evolution reaction. Nature Commun., 2022, 13, 4430.
  9. Wang, S.; Tang, S.; Lei, A.*, Tuning radical reactivity for selective radical/radical cross-coupling. Sci. Bull., 2018, 63, 1006-1009.
Full list
  • Zeng, L., Yang, Q., Wang, J., Wang, X., Wang, P., Wang, S., Lv, S., Muhammad, S., Liu, Y., Yi, H. & Lei, A. Programmed alternating current optimization of Cu-catalyzed C-H bond transformations. Science, 2024, 385, 216.
  • Zhang, Z., Yue, S., Jin, B., Yang, R., Wang, S., Zhang, T., Sun L., Lei, A. & Cai, H. Para-selective nitrobenzene amination lead by C(sp2)-H/N-H oxidative cross-coupling through aminyl radical. Nat. Commun. 2024, 15, 4186.
  • You, C.-M., Huang, C., Tang, S., Xiao, P., Wang, S., Wei, Z., Lei, A. & Cai, H. N-Allylation of azoles with hydrogen evolution enabled by visible-light photocatalysis. Org. Lett. 2023, 25, 1722-1726.
  • Xu, Y., Wang, S., Liu, Z., Guo, M. & Lei, A. Photo/Ni dual-catalyzed radical defluorinative sulfonylation to synthesize gem-difluoro allylsulfones. Chem. Commun. 2023, 59, 3707-3710.
  • Liu, X., Yang, D., Liu, Z., Wang, Y., Liu, Y., Wang, S., Wang, P., Cong, H., Chen, Y.-H., Lu, L., Qi, X., Yi, H. & Lei, A. Unraveling the structure and reactivity patterns of the indole radical cation in regioselective electrochemical oxidative annulations. J. Am. Chem. Soc. 2023, 145, 3175-3186.
  • Hu, J., Wang, S., Li, B. & Lei, A. K2S2O8-Induced [4+2] annulation of tertiary anilines and alkenes toward tetrahydroquinolines. Org. Lett. 2023, 25, 1252.
  • Hu, J., Wan, H., Wang, S., Yi, H. & Lei, A. Electrochemical thiocyanation/cyclization cascade to access thiocyanato-containing benzoxazines. Catalysts 2023, 13, 631.
  • Zeng, L., Jiao, Y., Yan, W., Wu, Y., Wang, S., Wang, P., Wang, D., Yang, Q., Wang, J., Zhang, H. & Lei, A. Asymmetric-waveform alternating current-promoted silver catalysis for C–H phosphorylation. Nat. Synth. 2023, 2, 172.
  • Yuan, Y., Liu, X., Hu, J., Wang, P., Wang, S., Alhumade, H. & Lei, A. Electrochemical oxidative N-H/P-H cross-coupling with H2 evolution towards the synthesis of tertiary phosphines. Chem. Sci. 2022, 13, 3002-3008.
  • You, S., Ruan, M., Lu, C., Liu, L., Weng, Y., Yang, G., Wang, S., Alhumade, H., Lei, A. & Gao, M. Paired electrolysis enabled annulation for the quinolyl-modification of bioactive molecules. Chem. Sci. 2022, 13, 2310-2316.
  • Yang, Z., Yang, D., Zhang, J., Tan, C., Li, J., Wang, S., Zhang, H., Huang, Z. & Lei, A. Electrophotochemical Ce-catalyzed ring-opening functionalization of cycloalkanols under redox-neutral conditions: scope and mechanism. J. Am. Chem. Soc. 2022, 144, 13895-13902.
  • Luo, X., Wang, S. & Lei, A. Electrochemical-induced hydroxysulfonylation of alpha-CF3 alkenes to access tertiary beta-hydroxysulfones. Adv. Synth. Catal. 2022, 364, 1016-1022.
  • Liang, Y., Niu, L., Xing-An, L., Wang, S., Wang, P. & Lei, A. Electrooxidation-induced C(sp3)-H/C(sp2)-H radical-radical cross-coupling between xanthanes and electron-rich arenes. Chin. J. Chem. 2022, 40, 1422-1428.
  • Liang, K., Wang, S., Cong, H., Lu, L. & Lei, A. Electrochemical oxidative 4+2 annulation of different styrenes toward the synthesis of 1,2 dihydronaphthalenes. CCS Chem. 2022, 4, 1557-1564.
  • Zhang, D., Yang, D., Wang, S., Zeng, L., Xin, J., Zhang, H. & Lei, A. The real structure of Pd(OAc)2 in various solvents. Chin. J. Chem. 2021, 39, 307-311.
  • Liu, Y., Shi, B., Liu, Z., Gao, R., Huang, C., Alhumade, H., Wang, S., Qi, X. & Lei, A. Time-resolved EPR revealed the formation, structure, and reactivity of N-centered radicals in an electrochemical C(sp3)-H arylation reaction. J. Am. Chem. Soc. 2021, 143, 20863-20872.
  • Liang, K., Lu, L., Liu, X., Yang, D., Wang, S., Gao, Y., Alhumade, H., Yi, H. & Lei, A. Electrochemical cobalt-catalyzed cyclotrimerization of alkynes to 1,2,4-substituted arenes. ACS Catal. 2021, 11, 14892-14897.
  • Yuan, Y., Zheng, Y., Xu, B., Liao, J., Bu, F., Wang, S., Hu, J.-G. & Lei, A. Mn-catalyzed Electrochemical radical cascade cyclization toward the synthesis of benzo 4,5 imidazo 2,1-a isoquinolin-6(5H)-one derivatives. ACS Catal. 2020, 10, 6676-6681.
  • Wang, Q., Wang, P., Gao, X., Wang, D., Wang, S., Liang, X., Wang, L., Zhang, H. & Lei, A. Regioselective/electro-oxidative intermolecular 3+2 annulation for the preparation of indolines. Chem. Sci. 2020, 11, 2181-2186.
  • Wan, Z., Wang, D., Yang, Z., Zhang, H., Wang, S. & Lei, A. Electrochemical oxidative C(sp3)-H azolation of lactams under mild conditions. Green Chem. 2020, 22, 3742-3747.
  • Liu, K., Song, W., Deng, Y., Yang, H., Song, C., Abdelilah, T., Wang, S., Cong, H., Tang, S. & Lei, A. Electrooxidation enables highly regioselective dearomative annulation of indole and benzofuran derivatives. Nat. Commun. 2020, 11, 3.
  • Cao, Y., Yang, J.-G., Deng, Y., Wang, S., Liu, Q., Shen, C., Lu, W., Che, C.-M., Chen, Y. & He, L. Amine-responsive disassembly of Au-I-Cu-I double salts for oxidative carbonylation. Angew. Chem. Int. Ed. 2020, 59, 2080-2084.
  • Bu, F., Lu, L., Hu, X., Wang, S., Zhang, H. & Lei, A. Electrochemical oxidative decarboxylation and 1,2-aryl migration towards the synthesis of 1,2-diaryl ethers. Chem. Sci. 2020, 11, 10000-10004.
  • Zanda, M., Niu, L., Liu, J., Wang, S., Liang, X.-A. & Lei, A. Visible-light-induced direct alpha C-H functionalization of alcohols. Synlett 2019, 30, A99-A101.
  • Wang, P., Yang, Z., Wang, Z., Xu, C., Huang, L., Wang, S., Zhang, H. & Lei, A. Electrochemical arylation of electron-deficient arenes through reductive activation. Angew. Chem. Int. Ed. 2019, 58, 15747-15751.
  • Wang, H., Li, Y., Lu, Q., Yu, M., Bai, X., Wang, S., Cong, H., Zhang, H. & Lei, A. Oxidation-induced beta-selective C-H Bond functionalization: thiolation and selenation of N-heterocycles. ACS Catal. 2019, 9, 1888-1894.
  • Song, C., Liu, K., Wang, Z., Ding, B., Wang, S., Weng, Y., Chiang, C.-W. & Lei, A. Electrochemical oxidation induced selective tyrosine bioconjugation for the modification of biomolecules. Chem. Sci. 2019, 10, 7982-7987.
  • Wang, D., Wang, P., Wang, S., Chen, Y.-H., Zhang, H. & Lei, A. Direct electrochemical oxidation of alcohols with hydrogen evolution in continuous-flow reactor. Nat. Commun. 2019, 10, 2796.
  • Niu, L., Liu, J., Wang, S., Liang, X.-A. & Lei, A. Visible-light-induced direct alpha C-H functionalization of alcohols. Synthesis-Stuttgart 2019, 51, A99-A101.
  • Niu, L., Liu, J., Liang, X.-A., Wang, S. & Lei, A. Visible light-induced direct alpha C-H functionalization of alcohols. Nat. Commun. 2019, 10, 467.
  • Liu, K., Tang, S., Wu, T., Wang, S., Zou, M., Cong, H. & Lei, A. Electrooxidative para-selective C-H/N-H cross-coupling with hydrogen evolution to synthesize triarylamine derivatives. Nat. Commun. 2019, 10, 639.
  • Liang, X.-A., Niu, L., Wang, S., Liu, J. & Lei, A. Visible-light-induced C(sp3)-H oxidative arylation with heteroarenes. Org. Lett. 2019, 21, 2441-2444.
  • Li, D., Li, S., Peng, C., Lu, L., Wang, S., Wang, P., Chen, Y.-H., Cong, H. & Lei, A. Electrochemical oxidative C-H/S-H cross-coupling between enamines and thiophenols with H2 evolution. Chem. Sci. 2019, 10, 2791-2795.
  • Guan, Z., Wang, H., Huang, Y., Wang, Y., Wang, S. & Lei, A. Electrochemical oxidative aryl(alkyl)trifluoromethylation of allyl alcohols via 1,2-migration. Org. Lett. 2019, 21, 4619-4622.
  • Zheng, C., Lu, F., Lu, H., Xin, J., Deng, Y., Yang, D., Wang, S., Huang, Z., Gao, M. & Lei, A. Copper-catalyzed selective radical-radical cross-coupling for C-S bond formation: an access to alpha-alkylthionitriles. Chem. Commun. 2018, 54, 5574-5577.
  • Zhang, L., Zhang, G., Li, Y., Wang, S. & Lei, A. The synergistic effect of self-assembly and visible-light induced the oxidative C-H acylation of N-heterocyclic aromatic compounds with aldehydes. Chem. Commun. 2018, 54, 5744-5747.
  • Wang, H., Li, Y., Tang, Z., Wang, S., Zhang, H., Cong, H. & Lei, A. Z-Selective addition of diaryl phosphine oxides to alkynes via photoredox catalysis. ACS Catal. 2018, 8, 10599-10605.
  • Huang, P., Wang, P., Wang, S., Tang, S. & Lei, A. Electrochemical oxidative 4+2 annulation of tertiary anilines and alkenes for the synthesis of tetrahydroquinolines. Green Chem. 2018, 20, 4870-4874.
  • Yi, H., Niu, L., Wang, S., Liu, T., Singh, A. K. & Lei, A. Visible-light-induced acetalization of adehydes with alcohols. Org. Lett. 2017, 19, 122-125.
  • Niu, L., Yi, H., Wang, S., Liu, T., Liu, J. & Lei, A. Photo-induced oxidant-free oxidative C-H/N-H cross-coupling between arenes and azoles. Nat. Commun. 2017, 8, 14226.
  • Niu, L., Liu, J., Yi, H., Wang, S., Liang, X.-A., Singh, A. K., Chiang, C.-W. & Lei, A. Visible-light-induced external oxidant-free oxidative phosphonylation of C(sp2)-H bonds. ACS Catal. 2017, 7, 7412-7416.

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